Diverse impacts of aging on insulin resistance in lean and obese women with polycystic ovary syndrome: evidence from 1345 women with the syndrome
نویسندگان
چکیده
منابع مشابه
Diverse impacts of aging on insulin resistance in lean and obese women with polycystic ovary syndrome: evidence from 1345 women with the syndrome.
BACKGROUND Polycystic ovary syndrome (PCOS) represents a moving spectrum of hormonal to metabolic abnormalities, as women with the syndrome are aging. Hormonal abnormalities, anovulation, and hyperandrogenic signs were predominant during the early years of PCOS and fade away with the years. Metabolic abnormalities and insulin resistance (IR) remain throughout the PCOS life cycle; however, it is...
متن کاملInsulin resistance and adverse metabolic profile in overweight/obese and normal weight of young women with polycystic ovary syndrome
Background: Polycystic ovary syndrome (PCOs) is an endocrine-metabolic disorder. This study intends to determine the comparison of insulin resistance (IR) and metabolic disturbance in overweight/obese and normal-weight of young women with polycystic ovary syndrome. Methods: Using a comparative cross-sectional study design in 2015, 27 normal weight (18<bmi Results: 112 women with PCOS participa...
متن کاملObesity and insulin resistance in women with polycystic ovary syndrome.
OBJECTIVE To evaluate the impact of obesity and various phenotypes of polycystic ovary syndrome (PCOS) on the insulin sensitivity index (ISI) and insulin resistance (IR). METHODS ISI and IR from 273 women in four phenotypes of PCOS and control groups were evaluated retrospectively. RESULTS The ISI and the percentage of IR were not significantly different among discrete phenotypes of PCOS gr...
متن کاملInsulin resistance in women with polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is associated with insulin resistance. There are also defects in pancreatic beta-cell function in affected women. These abnormalities are heritable. There are post-binding defects in insulin receptor signaling, with selective resistance to insulin's metabolic actions and constitutively activated mitogenic signaling in skeletal muscle. Intrinsic and environmental...
متن کاملEffect of Aerobic Training Program on Obesity and Insulin Resistance in Young Women with Polycystic Ovary Syndrome
OBJECTIVE: Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age characterized by the presence of polycystic ovaries, menstrual dysfunction and biochemical or clinical hyperandrogenism. Lifestyle modification is important in treatment of obese and overweight women with PCOS. This study was performed to evaluate the benefit of aerobic exercise training o...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2014
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje-13-1007